MFG-E8 Regulates Angiogenesis in Cutaneous Wound Healing
نویسندگان
چکیده
منابع مشابه
Pericyte-derived MFG-E8 regulates pathologic angiogenesis.
OBJECTIVE MFG-E8 (also called lactadherin and SED1) is a secreted glycoprotein that has been previously implicated in enhancement of vascular endothelial growth factor-dependent angiogenesis. Major sources of MFG-E8 in vivo and precise mechanisms of MFG-E8 action remain undetermined. The objective of this study was to identify important sources of MFG-E8 in vivo and further elucidate the role(s...
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BACKGROUND Fibromodulin (FMOD) plays a critical role in the wound-healing process. Our previous studies revealed that FMOD deficiency led to marked alterations in adult wound healing characterized by delayed dermal cell migration, postponed wound closure, and increased scar formation, all accompanied by impeded angiogenesis. Therefore, the aim of this study was to reveal the effect of FMOD on a...
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A simple model of wound healing angiogenesis is presented, and investigated using numerical and asymptotic techniques. The model captures many key qualitative features of the wound healing angiogenic response, such as the propagation of a structural unit into the wound centre. A detailed perturbative study is pursued, and is shown to capture all features of the model. This enables one to show t...
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ژورنال
عنوان ژورنال: The KITAKANTO Medical Journal
سال: 2015
ISSN: 1343-2826,1881-1191
DOI: 10.2974/kmj.65.119